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Developments in Multi-Gene Panel Tests for Breast Cancer

Numerous genetic mutations are linked to increased risk for breast cancer. Genetic testing can identify these mutations and guide patient management decisions. Over the past decade, multi-gene panel tests have gained traction in clinical settings. These evaluate up to 43 breast cancer-related genes, compared with limited BRCA 1 and BRCA2 (BRCA1/2) tests. In a recent review for World Journal of Surgical Procedures, I discussed whether multi-gene panel testing should replace limited BRCA1/2 testing.

Background to Genetic Testing

Since the mid-1990s, we have known about the link between BRCA1/2 and risk for breast cancer, which account for 30 to 50 percent of breast cancers. There are now well-established clinical guidelines for the […]

The Impact of Multi-Gene Panel Testing for Cancer Survivors

Multi-gene panel testing has recently emerged as a safe and effective way to identify genetic mutations known to increase risk for breast cancer. Compared with earlier genetic tests, which required initial testing for BRCA1 and BRCA2 followed by subsequent testing for other cancer-related genes, multi-gene panel testing can evaluate up to 43 genes. At Breastlink, we recently conducted a study to see how multi-gene panel testing affected treatment and screening decisions in cancer survivors who had previously tested negative for BRCA1/2.

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How Does Management Change for Cancer Survivors with Positive Results?

For our study, we retrospectively collected data from 914 Breastlink patients who […]

The 2015 ASCO Breast Cancer Symposium in Review

Every year, the American Society of Clinical Oncologists hosts a Breast Cancer Symposium to promote discussion about developments in breast cancer care and treatment. This event is an exceptional opportunity to learn about current trends and future directions that affect our patients and our daily practice. I was excited to attend the 2015 ASCO Breast Cancer Symposium and appreciate the thought-provoking dialogue that occurred.  In addition, I was also invited to present our own data on multi-gene panel testing.

Several topics of interest included the development of a new model for evaluating breast cancer risk in women with atypical hyperplasia, new data on recurrence in women with ductal carcinoma in situ […]

Personalized Care & Breast Cancer Screening: A Response to Revised ACS Guidelines

Middle Aged Woman Getting Mammogram

Breast cancer is a common and still lethal disease in the United States. More than 230,000 are likely to be diagnosed with breast cancer this year and it is expected to claim more than 40,000 lives.[1] Early detection of breast cancer saves lives and can minimize treatment.

Earlier this year, Breastlink responded to updated U.S. Preventive Services Task Force (USPSTF) recommendations to delay screening mammography until age 50 by emphatically detailing the potential harms of delaying a cancer diagnosis. These harms include increased toxicity of chemotherapy, more extensive surgery and a higher risk of lymphedema, as well […]

Early Detection of Breast Cancer

Early detection of breast cancer offers women the best possible chance for optimal treatment. As with many cancers, breast cancer is more easily managed and treated when it is still small. To ensure early detection of breast cancer, women should educate themselves about appropriate screening and breast health care.

Why is Early Detection of Breast Cancer Important?

When breast cancer is diagnosed before it has spread or grown too large, it is more likely to be treated successfully. Five-year relative survival rates in women diagnosed with early stage breast cancers rise above 90 percent, according to the American Cancer Society.

However, this number drops to 22 percent in women diagnosed with late stage […]

By |September 14, 2015|Categories: Breast Cancer Screening|0 Comments

Breast Cancer Detection

Learning about breast cancer detection can potentially save your life. Early detection of breast cancer provides the best chance for optimal treatment outcomes. For the last several decades, breast cancer awareness initiatives have helped to reduce deaths from breast cancer. To ensure breast cancer patients receive appropriate care, educational efforts on breast cancer detection continue to remain relevant.

Breast Self-Examination

Breast self-examination can enable breast cancer detection. Breast self-exam is ideally performed after each menstrual cycle when the breast tissue is least likely to be swollen.

To perform breast self-examination, look at your breasts in the mirror. Check that they are their normal size, shape and color. Look for signs of breast cancer, […]

Breast Cancer and Genetics

In true Hollywood fashion, when a celebrity speaks the masses listen.

That’s precisely what happened when Angelina Jolie penned an editorial in The New York Times that shined the spotlight on breast cancer and genetics, specifically genes that can cause the disease.

Quickly dubbed the “Angelina Jolie Effect,” the number of women requesting a blood test to reveal if they’re carriers of the BRCA1 and BRCA2 genes has nearly doubled since the editorial’s 2013 publication, according to various studies including one by the online journal Breast Cancer Research.

Although inherited factors account for less than 5 percent of breast cancer cases, individuals […]

Early Signs of Breast Cancer

Identifying the early signs of breast cancer can significantly increase your chances of recovery and cure from this disease. Though many breast cancers are detectable only through a mammogram or other imaging studies, a significant number of early diagnoses have come as the result of patients recognizing one or more common breast cancer signs. […]

BRCA Testing: What Patients Should Know

In recent years, many advancements have been made in our knowledge of the relationship between genetics and breast cancer. Tests are now available to help identify numerous genetic mutations that increase your risk for breast cancer. BRCA1 and BRCA2 are two genes that have been linked to increased risk for breast cancer. BRCA testing could potentially help you to make informed decisions regarding your breast health. […]

How Do Single-Gene & Multi-Gene Tests Compare?

The landscape of testing for hereditary cancer predisposition genes has been in rapid evolution. Recently developed tests can evaluate up to 43 genetic mutations associated with increased risk for a variety of cancers including breast cancer. Using data collected from our clinics, my Breastlink colleagues and I have analyzed how safe and effective these newer multi-gene tests are in comparison to previous methods of genetic testing.

Genetic Mutations breast cancer | gene tests

The Development of Multi-Gene Tests for Breast Cancer Risk

Two key events have helped change the face of genetic testing:

  • Technology became so advanced with next generation sequencing that it became as simple […]
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