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How Do Single-Gene & Multi-Gene Tests Compare?

The landscape of testing for hereditary cancer predisposition genes has been in rapid evolution. Recently developed tests can evaluate up to 43 genetic mutations associated with increased risk for a variety of cancers including breast cancer. Using data collected from our clinics, my Breastlink colleagues and I have analyzed how safe and effective these newer multi-gene tests are in comparison to previous methods of genetic testing.

Genetic Mutations breast cancer | gene tests

The Development of Multi-Gene Tests for Breast Cancer Risk

Two key events have helped change the face of genetic testing:

  • Technology became so advanced with next generation sequencing that it became as simple […]

BRCA 1 and BRCA2 Genes: What Do Women Need to Know?

Inherited genetic mutations can increase a woman’s risk of developing breast cancer. For instance, a mutation in two of the better-understood genes linked to a substantial increased risk of breast cancer, the BRCA1 and BRCA2 genes, account for up to:

  • 10 percent of all breast cancers.
  • 50 percent of hereditary breast cancers (caused by inherited genetic mutations).

Women with a strong family history of breast cancer should take time to learn how genetic testing is appropriate for them. It is important to remember that risk can be passed down from either your father or mother. A detailed knowledge of the medical history of your relatives can be extremely helpful.

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Understanding Advancements in Genetic Testing for Breast Cancer

Our understanding of breast cancer is rapidly advancing. Breast cancer is not a single disease entity, but a heterogeneous disease spectrum with numerous genetic alterations involved in its pathogenesis.

  • Some breast cancers are indolent and not life-threatening, while others are very aggressive.
  • Similarly, we find different genetic alterations in different breast cancers.
  • Some of these genetic changes are familial, or the result of genetic mutations passed from parent to child.

The BRCA genes were the first to shed light on familial breast cancer genetics. Now we are capable of screening over a dozen different genes for mutations implicated in breast cancer risk. Navigating these new complexities in genetic testing can be […]

Inheriting a BRCA1 or BRCA2 Gene Mutation | Interview with Dr. Ihde

While there is a range of breast cancer risk factors patients need to be aware, inheriting a BRCA1 or BRCA2 gene mutation is considered one of the strongest indications a patient may face a breast cancer diagnosis in their lifetime. Women with a positive BRCA1 or BRCA2 gene mutation have up to an 87 percent chance of being diagnosed with breast cancer during the course of their life. As such, it is natural for women to have questions about whether testing for a BRCA1 or BRCA2 gene mutation is appropriate for them.

Dr. Janet IhdeDr. Janet Ihde, our surgical oncologist at the Chrysalis […]

By |May 6, 2013|Categories: Breast Cancer Risks|Tags: |0 Comments
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