One Center • One Focus • One Team

Genetic Testing

HomeTag:Genetic Testing

How Do Single-Gene & Multi-Gene Tests Compare?

The landscape of testing for hereditary cancer predisposition genes has been in rapid evolution. Recently developed tests can evaluate up to 43 genetic mutations associated with increased risk for a variety of cancers including breast cancer. Using data collected from our clinics, my Breastlink colleagues and I have analyzed how safe and effective these newer multi-gene tests are in comparison to previous methods of genetic testing.

Genetic Mutations breast cancer | gene tests

The Development of Multi-Gene Tests for Breast Cancer Risk

Two key events have helped change the face of genetic testing:

  • Technology became so advanced with next generation sequencing that it became as simple […]

SABCS 2014: Breast Cancer Prevention, Screening & Genetic Testing

This year at the San Antonio Breast Cancer Symposium (SABCS) there were two aspects of breast cancer that were clearly emphasized: use of ovarian suppression in premenopausal women with breast cancer and advances in genetic testing for hereditary cancer predisposition.

San Antonio Breast Cancer Symposium 2014
Results of the SOFT trial (further detailed by Dr. Wade Smith in this post), show a clear benefit to the addition of ovarian suppression in women under the age of 35. This benefit resembles that seen with the addition of Herceptin for HER2+ cancer, and now calls for a change in practice management.

The second “call for action” released […]

BRCA 1 and BRCA2 Genes: What Do Women Need to Know?

Inherited genetic mutations can increase a woman’s risk of developing breast cancer. For instance, a mutation in two of the better-understood genes linked to a substantial increased risk of breast cancer, the BRCA1 and BRCA2 genes, account for up to:

  • 10 percent of all breast cancers.
  • 50 percent of hereditary breast cancers (caused by inherited genetic mutations).

Women with a strong family history of breast cancer should take time to learn how genetic testing is appropriate for them. It is important to remember that risk can be passed down from either your father or mother. A detailed knowledge of the medical history of your relatives can be extremely helpful.

[…]

Breast Cancer Genetic Testing – Battle for the Breasts

Bethany Hamilton emerged the winner in Surfline’s Battle for the Breasts, a friendly online video competition among some of the world’s best female surfers to raise awareness around breast cancer genetic testing. Participating on behalf of Breastlink and the Cancer Research Collaboration, Hamilton’s victory provided us the opportunity to offer our patients $50,000 worth of genetic testing courtesy of Ambry Genetics.

Breast Cancer Genetic Testing | Orange County, CA

Battle for the Breasts surfers promote breast cancer awareness.

Breastlink and the Cancer Research Collaboration were honored to have Bethany Hamilton as its representative in Battle for the […]

Understanding Advancements in Genetic Testing for Breast Cancer

Our understanding of breast cancer is rapidly advancing. Breast cancer is not a single disease entity, but a heterogeneous disease spectrum with numerous genetic alterations involved in its pathogenesis.

  • Some breast cancers are indolent and not life-threatening, while others are very aggressive.
  • Similarly, we find different genetic alterations in different breast cancers.
  • Some of these genetic changes are familial, or the result of genetic mutations passed from parent to child.

The BRCA genes were the first to shed light on familial breast cancer genetics. Now we are capable of screening over a dozen different genes for mutations implicated in breast cancer risk. Navigating these new complexities in genetic testing can be […]

Load More Posts