Locally advanced breast cancers are large cancers that are often fixed to the skin or the underlying chest wall muscles, and may be associated with large underarm lymph nodes. There is however, no associated skin redness (if there is redness we classify them as inflammatory breast cancers). These cancers have a better prognosis than do breast cancers with an associated inflammatory process.

The diagnosis of these locally advanced breast cancer tumors is straight-forward. We do a mammogram of both breasts and then do a core biopsy of the tumor. A metastatic workup is performed and a course of chemotherapy is given.

In most cases this is followed by mastectomy and irradiation. The following link to two cases clinical cases which were successfully treated for locally advanced breast cancer. The following 2 examples are of patients recently treated at Breastlink. Please note these pictures are graphic and viewer discretion is advised.

Locally Advanced Breast Cancer Cases

Case Study A:
Treatment of locally advanced breast cancer with rectus abdominis flap. Elderly female presenting with large locally advanced breast cancer on the left. This patient was initially treated with chemotherapy with approximately 80 percent reduction in tumor size. The breast was removed and the defect closed with a Tram flap. She responded well to the surgical procedure.
Example 2:
Treatment of a locally advanced breast cancer with vertical rectus abdominis flap. A young women presented with a locally advanced breast cancer and was treated with neoadjuvant chemotherapy. She had only a partial response to therapy and had poorly controlled chest wall pain. A wide removal of the tumor was performed and a Tram flap reconstruction was used to close the mastectomy wound.